Choose the wrong statement_________ .

A. Hybridization of DNA by a probe requires sequence similarity between the two components.

B. The circular and linear DNAs, containing N restriction sites for a restriction enzyme, give, respectively, N and N + 1 fragments, once cut by this enzyme.

C. Cloning of a recombinant DNA means the isolation of cell colonies containing the construct of the specific recombinant DNA.

D. The EcoRI endonuclease, the cut of which on a circular DNA gives 4 fragments, is in favor of the presence of 4 restriction sites.